Slingerland D W, Cardarelli J A, Burrows B A, Miller A
Arch Intern Med. 1984 Jun;144(6):1167-8.
Elevated levels of serum gastrin as a consequence of gastric achlorhydria are characteristic of clinical pernicious anemia. In a largely male hospitalized population with an average age of 64 years, 7.7% had low levels of serum B12 (less than 170 pg/mL); only 2.5% of these had frank pernicious anemia. In an attempt to separate a subgroup with low levels of serum B12 in whom pernicious anemia may later develop, their serum gastrin levels were determined. Twenty-two percent had high values and, of these, 70% had low B12 absorptions. In patients with low serum B12 levels, serum gastrin assays may be useful in determining those in whom clinical pernicious anemia seems likely to develop.
胃酸缺乏导致血清胃泌素水平升高是临床恶性贫血的特征。在一个平均年龄为64岁的主要为男性的住院人群中，7.7%的人血清B12水平较低（低于170 pg/mL）；其中只有2.5%患有明显的恶性贫血。为了区分出可能随后发展为恶性贫血的血清B12水平较低的亚组，测定了他们的血清胃泌素水平。22%的人胃泌素水平较高，其中70%的人B12吸收较低。对于血清B12水平较低的患者，血清胃泌素检测可能有助于确定那些似乎可能发展为临床恶性贫血的患者。
