保育箱噪音会增加氨基糖苷类药物耳毒性的风险吗？
Does incubator noise increase risks of aminoglycoside ototoxicity?
作者信息
Bernard P A, Pechère J C
出版信息
Audiology. 1984;23(3):309-20. doi: 10.3109/00206098409072842.
PMID:6732634
Abstract
One group of newborn rats were given 50 mg/kg gentamicin for 20 days, 8 days after birth and were housed during the treatment in a regular incubator. They were compared to a similar group housed in regular cages and to two groups of unintoxicated newborn rats, one being exposed to the incubator noise and one being unexposed. Incubator noise was found to have no influence on gentamicin ototoxicity and to induce only a temporary threshold shift.
摘要
一组新生大鼠在出生后8天给予50毫克/千克庆大霉素，持续20天，并在治疗期间饲养在常规培养箱中。将它们与饲养在常规笼子中的类似组以及两组未中毒的新生大鼠进行比较，其中一组暴露于培养箱噪音中，另一组未暴露。发现培养箱噪音对庆大霉素耳毒性没有影响，仅引起暂时的阈值偏移。
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引用本文的文献
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Experimental investigations on the influence of anemia on gentamicin ototoxicity.贫血对庆大霉素耳毒性影响的实验研究
Eur Arch Otorhinolaryngol. 1991;248(6):342-4. doi: 10.1007/BF00169026.
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