Delb W, Koch A, Federspil P
University ENT Department, Homburg/Saar, Federal Republic of Germany.
Eur Arch Otorhinolaryngol. 1991;248(6):342-4. doi: 10.1007/BF00169026.
The purpose of this study was to determine whether or not anemic patients have a higher risk of gentamicin ototoxicity. Using the laboratory rat as an animal model with auditory brain-stem response measurements and surface preparations of the organ of Corti, it could be shown that cochlear damage in anemic rats treated with gentamicin was significantly higher (P less than 0.05) than in the nonanemic ones treated with the same dosages of antibiotic. Doses of gentamicin used were 50 mg/kg for 30 days and 40 mg/kg for another 75 days.
本研究的目的是确定贫血患者是否有更高的庆大霉素耳毒性风险。以实验大鼠作为动物模型，通过听觉脑干反应测量和柯蒂氏器的表面制备，结果表明，用相同剂量抗生素治疗的贫血大鼠的耳蜗损伤明显高于非贫血大鼠（P小于0.05）。所用庆大霉素剂量为50mg/kg，持续30天，然后40mg/kg，再持续75天。
