Cardon S B, Larson D F, Russell D H
Biochem Biophys Res Commun. 1984 Apr 30;120(2):614-8. doi: 10.1016/0006-291x(84)91299-3.
Within one hr of the administration of cyclosporine to rats, there was a 4-fold elevation in the serum prolactin concentration. Doses of 0.12, 1.2, and 12 micrograms/100 g body weight cyclosporine significantly elevated the serum prolactin level. Higher doses, 120 or 1200 micrograms/100 g body weight cyclosporine resulted in small but insignificant elevations of the serum prolactin concentration. Bromocriptine, a dopamine agonist which inhibits prolactin release from the anterior pituitary, completely blocked the elevation in serum prolactin in response to cyclosporine alone. These data suggest that the ability of cyclosporine to suppress immune function may involve its ability to rapidly produce hyperprolactinemia.
给大鼠注射环孢素后1小时内，血清催乳素浓度升高了4倍。剂量为0.12、1.2和12微克/100克体重的环孢素显著提高了血清催乳素水平。更高剂量，即120或1200微克/100克体重的环孢素，导致血清催乳素浓度有小幅但不显著的升高。溴隐亭是一种抑制垂体前叶释放催乳素的多巴胺激动剂，它能完全阻断仅由环孢素引起的血清催乳素升高。这些数据表明，环孢素抑制免疫功能的能力可能涉及其迅速产生高催乳素血症的能力。
