Kahn D, Zeng Q, Kajani M, Eagon P K, Lai H, Makowka L, Starzl T E, Van Thiel D H
Department of Surgery, University of Pittsburgh School of Medicine, PA 15261.
J Invest Surg. 1989;2(2):125-33. doi: 10.3109/08941938909015344.
Mammalian liver contains receptors for both estrogens and androgens. Hepatic regeneration after partial hepatectomy in male rats is associated with a loss of certain male-specific hepatic characteristics. In this study we investigated the effects of lesser forms of hepatic injury on the levels of estrogen and androgen receptor activity in the liver. Adult male rats were subjected to portacaval shunt, partial portal vein ligation, hepatic artery ligation, or two-thirds partial hepatectomy. Another group of animals was treated with cyclosporine. At the time of sacrifice the livers were removed and used to determine the estrogen and androgen receptor activity in the hepatic cytosol. A significant reduction (p less than 0.05) in the hepatic cytosolic androgen receptor activity and a slight increase in the estrogen receptor activity occurred following total portosystemic shunting. Partial ligation of the portal vein, which produces a lesser degree of portosystemic shunting, had no effect on the levels of the estrogen and androgen receptor activity present within hepatic cytosol. Cyclosporine-treated animals had significantly greater (p less than 0.01) levels of estrogen receptor activity in the hepatic cytosol compared to vehicle-treated control animals. Levels of estrogen and androgen receptor activity within the hepatic cytosol remained unchanged after ligation of the hepatic artery. The reduction in the cytosolic estrogen and androgen receptor activity in the liver after partial hepatectomy was confirmed. In summary, certain types of hepatic injury are associated with profound changes in the estrogen and androgen receptor content within the liver.
哺乳动物的肝脏含有雌激素和雄激素的受体。雄性大鼠部分肝切除术后的肝再生与某些雄性特有的肝脏特征丧失有关。在本研究中，我们调查了较轻形式的肝损伤对肝脏中雌激素和雄激素受体活性水平的影响。成年雄性大鼠接受门腔分流术、部分门静脉结扎术、肝动脉结扎术或三分之二肝切除术。另一组动物用环孢素治疗。在处死时，取出肝脏并用于测定肝细胞质中的雌激素和雄激素受体活性。完全门体分流术后，肝细胞质雄激素受体活性显著降低（p<0.05），雌激素受体活性略有增加。部分门静脉结扎术产生的门体分流程度较轻，对肝细胞质中存在的雌激素和雄激素受体活性水平没有影响。与用载体处理的对照动物相比，用环孢素处理的动物肝细胞质中雌激素受体活性水平显著更高（p<0.01）。肝动脉结扎后，肝细胞质中雌激素和雄激素受体活性水平保持不变。部分肝切除术后肝脏中细胞质雌激素和雄激素受体活性的降低得到证实。总之，某些类型的肝损伤与肝脏中雌激素和雄激素受体含量的深刻变化有关。
