细胞外钙可保护分离的大鼠肝细胞免受损伤。
Extracellular calcium protects isolated rat hepatocytes from injury.
作者信息
Fariss M W, Olafsdottir K, Reed D J
出版信息
Biochem Biophys Res Commun. 1984 May 31;121(1):102-10. doi: 10.1016/0006-291x(84)90693-4.
PMID:6732796
Abstract
The incubation of isolated rat hepatocytes in calcium-free medium resulted in a pronounced increase in lipid peroxidation, mitochondrial and cytoplasmic glutathione depletion, glutathione disulfide formation and efflux of reduced glutathione as compared with hepatocytes incubated in calcium containing medium. These data suggest that extracellular calcium ions serve a protective role in isolated rat hepatocytes against cell injury.
摘要
与在含钙培养基中孵育的肝细胞相比，在无钙培养基中孵育分离的大鼠肝细胞会导致脂质过氧化显著增加、线粒体和细胞质谷胱甘肽耗竭、二硫化谷胱甘肽形成以及还原型谷胱甘肽外流。这些数据表明，细胞外钙离子在分离的大鼠肝细胞中对细胞损伤起到保护作用。
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