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急性低强度微波对戊巴比妥诱导的体温过低的影响取决于暴露方向。

Effects of acute low-level microwaves on pentobarbital-induced hypothermia depend on exposure orientation.

作者信息

Lai H, Horita A, Chou C K, Guy A W

出版信息

Bioelectromagnetics. 1984;5(2):203-11. doi: 10.1002/bem.2250050208.

DOI:10.1002/bem.2250050208
PMID:6732876
Abstract

Two series of experiments were performed to study the effects of acute exposure (45 min) to 2,450-MHz circularly polarized, pulsed microwaves [1 mW/cm2, 2-mus pulses, 500 pps, specific absorption rate (SAR) 0.6 W/kg] on the actions of pentobarbital in the rat. In the first experiment, rats were irradiated with microwaves and then immediately injected with pentobarbital. Microwave exposure did not significantly affect the extent of the pentobarbital-induced fall in colonic temperature. However, the rate of recovery from the hypothermia was significantly slower in the microwave-irradiated rats and they also took a significantly longer time to regain their righting reflex. In a second experiment, rats were first anesthetized with pentobarbital and then exposed to microwaves with their heads either pointing toward the source of microwaves (anterior exposure) or pointing away (posterior exposure). Microwave radiation significantly retarded the pentobarbital-induced fall in colonic temperature regardless of the orientation of exposure. However, the recovery from hypothermia was significantly faster in posterior-exposed animals compared to those of the anterior-exposed and sham-irradiated animals. Furthermore, the posterior-exposed rats took a significantly shorter time to regain their righting reflex than both the anterior-exposed and sham-irradiated animals.

摘要

进行了两组实验,以研究急性暴露(45分钟)于2450兆赫圆极化脉冲微波[1毫瓦/平方厘米,2微秒脉冲,500脉冲/秒,比吸收率(SAR)0.6瓦/千克]对大鼠戊巴比妥作用的影响。在第一个实验中,大鼠先接受微波照射,然后立即注射戊巴比妥。微波暴露对戊巴比妥引起的结肠温度下降程度没有显著影响。然而,微波照射的大鼠体温过低的恢复速度明显较慢,它们恢复翻正反射的时间也明显更长。在第二个实验中,大鼠先用戊巴比妥麻醉,然后头部朝向微波源(前向暴露)或远离微波源(后向暴露)接受微波照射。无论暴露方向如何,微波辐射都显著延缓了戊巴比妥引起的结肠温度下降。然而,与前向暴露和假照射的动物相比,后向暴露动物体温过低的恢复速度明显更快。此外,后向暴露的大鼠恢复翻正反射的时间明显短于前向暴露和假照射的动物。

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1
Effects of acute low-level microwaves on pentobarbital-induced hypothermia depend on exposure orientation.急性低强度微波对戊巴比妥诱导的体温过低的影响取决于暴露方向。
Bioelectromagnetics. 1984;5(2):203-11. doi: 10.1002/bem.2250050208.
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引用本文的文献

1
Effects of low-level microwave irradiation on amphetamine hyperthermia are blockable by naloxone and classically conditionable.低强度微波辐射对苯丙胺所致体温过高的影响可被纳洛酮阻断,且具有经典条件反射性。
Psychopharmacology (Berl). 1986;88(3):354-61. doi: 10.1007/BF00180838.