Church M W, Williams H L, Holloway J A
Brain Res. 1984 May;316(1):23-31. doi: 10.1016/0165-3806(84)90005-1.
Normal postnatal development of the scalp-recorded cochlear microphonic (CM) response and brainstem auditory evoked potential (BAEP) were studied in rat pups. BAEP latencies decreased and amplitudes increased as a function of maturation. These changes occurred rapidly between 14 and 23 days of age with gradual change occurring thereafter. The observed latency changes indicated that the auditory pathway matures in a sequential manner from the most peripheral to the most rostral structures. For example, CM latency stabilized (matured) by day 17 while BAEP wave I and II latencies stabilized by days 23 and 35, respectively. BAEP waves III and IV still showed significant latency decreases between days 42 and 70. The between-litter variability for CM and BAEP wave latencies also decreased with age. In contrast to peak latency measures, CM and BAEP amplitudes followed an independent time course of postnatal development. CM amplitude did not increase significantly after day 14. Amplitudes of all 4 BAEP components increased steadily from day 14 to 29, then stabilized. Unlike latency variability, amplitude variability was independent of age. There were no significant gender-dependent differences in amplitudes or latencies between the ages of 14 and 70 days.
研究了幼鼠头皮记录的耳蜗微音电位（CM）反应和脑干听觉诱发电位（BAEP）的正常产后发育情况。BAEP潜伏期随成熟度降低，波幅随成熟度增加。这些变化在14至23日龄之间迅速发生，此后逐渐变化。观察到的潜伏期变化表明，听觉通路从最外周到最头端结构按顺序成熟。例如，CM潜伏期在第17天稳定（成熟），而BAEP波I和波II潜伏期分别在第23天和第35天稳定。BAEP波III和波IV在第42天至第70天之间仍显示出明显的潜伏期缩短。CM和BAEP波潜伏期的窝间变异性也随年龄降低。与峰潜伏期测量不同，CM和BAEP波幅遵循独立的产后发育时间进程。CM波幅在第14天后没有显著增加。所有4个BAEP成分的波幅从第14天到第29天稳步增加，然后稳定。与潜伏期变异性不同，波幅变异性与年龄无关。在14至70日龄之间，波幅或潜伏期没有显著的性别依赖性差异。
