Seidenwurm D J, Elmer E B, Kaplan L M, Williams E K, Morris D G, Hoffman A R
Cancer. 1984 Aug 1;54(3):552-7. doi: 10.1002/1097-0142(19840801)54:3<552::aid-cncr2820540328>3.0.co;2-r.
Metastases to the adrenal glands are common in patients with cancer but symptomatic Addison's disease is rarely noted in this population. The development of body computerized tomography (CT) allows the diagnosis of adrenal metastases to be made more readily antemortem. From 1980 to 1981, 19% (4/21) of patients at the Massachusetts General Hospital who had metastatic cancer and who were noted to have enlarged adrenal glands on CT also had or developed symptomatic adrenal insufficiency. The case histories of 8 patients with Addison's disease and one patient with adrenal hemorrhage on the basis of metastatic infiltration are reviewed. Since adrenal insufficiency may develop abruptly in this group of patients, it is suggested that prophylactic maintenance glucocorticoid therapy be initiated as soon as the diagnosis of adrenal metastases is made.
癌症患者发生肾上腺转移很常见，但该人群中出现症状性艾迪生病却很少见。全身计算机断层扫描（CT）的发展使得肾上腺转移的诊断在生前更容易做出。1980年至1981年，马萨诸塞州总医院有转移癌且CT显示肾上腺增大的患者中，19%（4/21）出现或发展为症状性肾上腺功能不全。本文回顾了8例艾迪生病患者及1例因转移浸润导致肾上腺出血患者的病历。鉴于这类患者可能会突然发生肾上腺功能不全，建议一旦诊断为肾上腺转移，应立即开始预防性维持糖皮质激素治疗。
