继发于肾上腺淋巴瘤浸润的艾迪生病。化疗后肾上腺皮质功能恢复。

Addison's disease secondary to lymphomatous infiltration of the adrenal glands. Recovery of adrenocortical function after chemotherapy.

作者信息

Carey R W, Harris N, Kliman B

出版信息

Cancer. 1987 Mar 15;59(6):1087-90. doi: 10.1002/1097-0142(19870315)59:6<1087::aid-cncr2820590607>3.0.co;2-a.

DOI:10.1002/1097-0142(19870315)59:6<1087::aid-cncr2820590607>3.0.co;2-a

Abstract

This case represents the first known instance of reversal of Addison's disease after antineoplastic therapy. Malignant infiltration of the adrenal glands was demonstrated by cytologic findings of needle biopsy in a 57-year-old man suffering from disseminated large cell lymphoma and Addison's disease. He was treated with combination chemotherapy and adrenal hormone replacement. Improvement shown in his computed tomography (CT) scan and clinical status led to the successful discontinuance of cortisone and 9-alpha fluorohydrocortisone. Basal adrenal function and response to ACTH stimulation recovered.

摘要

该病例是已知的首例抗肿瘤治疗后艾迪生病逆转的实例。一名患有弥漫性大细胞淋巴瘤和艾迪生病的57岁男性，经针吸活检的细胞学检查证实肾上腺存在恶性浸润。他接受了联合化疗和肾上腺激素替代治疗。计算机断层扫描（CT）检查结果和临床状况的改善，使得可的松和9-α氟氢可的松得以成功停用。基础肾上腺功能及对促肾上腺皮质激素（ACTH）刺激的反应得以恢复。