Murray K H, Paolino F, Goldman J M, Galton D A, Grindle C F
Lancet. 1977 Apr 16;1(8016):829-31. doi: 10.1016/s0140-6736(77)92777-5.
Three patients with treated acute lymphoblastic leukaemia acquired visual symptoms believed to be caused by ocular infiltration by malignant cells. All three patients had other evidence of systemic disease including bone-marrow involvement at the time. One patient had a previous history of meningeal leukaemia and none had received "prophylactic" cranial irradiation. The ophthalmoscopic appearances were similar in each case and were thought to have been caused by obstruction of axoplasmic flow associated with infiltration of the optic nerve by neoplastic cells. The three patients were treated by local irradiation and two also received intrathecal chemotherapy. Response to treatment was variable but the use of radiotherapy combined with intrathecal cytoxic drugs is probably the best available approach.
三名接受过治疗的急性淋巴细胞白血病患者出现了据信由恶性细胞眼部浸润引起的视觉症状。当时，这三名患者均有包括骨髓受累在内的全身疾病的其他证据。一名患者曾有脑膜白血病病史，且均未接受过“预防性”颅脑照射。每例患者的眼底镜表现相似，被认为是由肿瘤细胞浸润视神经导致轴浆流受阻所致。这三名患者接受了局部照射治疗，其中两名还接受了鞘内化疗。治疗反应不一，但放疗联合鞘内细胞毒性药物可能是目前最佳的治疗方法。
