Nikaido H, Mishima H, Ono H, Choshi K, Dohy H
Department of Ophthalmology, Hiroshima University School of Medicine, Japan.
Am J Ophthalmol. 1988 Mar 15;105(3):294-8. doi: 10.1016/0002-9394(88)90013-x.
We studied five cases of leukemia with invasion of the optic disk and optic nerve. Two patients had acute lymphoblastic leukemia and three had acute myelogenous leukemia. All patients received intrathecal injections of chemotherapeutic drugs including methotrexate, cytarabine, and prednisolone. Three patients underwent irradiation therapy of the whole brain and optic nerve. While initial improvement in the ophthalmic abnormalities, such as optic disk edema, flame-shaped retinal hemorrhages, and dilation of the retinal vein, was noted, optic atrophy was later found in all eyes.
我们研究了5例白血病侵犯视盘和视神经的病例。2例患者患有急性淋巴细胞白血病，3例患有急性髓细胞白血病。所有患者均接受了鞘内注射包括甲氨蝶呤、阿糖胞苷和泼尼松龙在内的化疗药物。3例患者接受了全脑和视神经的放射治疗。虽然最初观察到眼部异常如视盘水肿、火焰状视网膜出血和视网膜静脉扩张有所改善，但后来所有眼睛均出现视神经萎缩。
