Waldenlind E, Sääf J, Ekbom K, Ross S, Wahlund L O, Wetterberg L
Cephalalgia. 1984 Jun;4(2):125-34. doi: 10.1046/j.1468-2982.1984.0402125.x.
Platelet monoamine oxidase activity (MAO) from 33 cluster headache patients (17 males, 16 females) and 34 migraine patients (16 males, 18 females) was assayed. The kinetic constants (apparent Vmax and apparent Km) and the thermolability, measured as the ratio of the platelet MAO activity after and before heat treatment (+52 degrees C, 30 min), were determined. The MAO activity and Vmax values were significantly lower in cluster headache than in migraine and in both headache disorders compared to a control group (62 males, 66 females). When comparing all groups, Km was not significantly different except for migraine females, who had lower Km values compared to control females. Thermolability was significantly higher in cluster headache than in migraine and in both headache disorders compared to the control group. Smokers of five cigarettes or more per day had significantly lower Vmax values but similar Km and thermolability values compared to those smoking less or nothing. The findings of low maximal velocities and high thermolability of platelet MAO in cluster headache and migraine are suggested to represent constitutionally different enzyme properties.
对33名丛集性头痛患者（17名男性，16名女性）和34名偏头痛患者（16名男性，18名女性）的血小板单胺氧化酶活性（MAO）进行了测定。测定了动力学常数（表观Vmax和表观Km）以及热稳定性，热稳定性通过热处理前后（52摄氏度，30分钟）血小板MAO活性的比值来衡量。与对照组（62名男性，66名女性）相比，丛集性头痛患者的MAO活性和Vmax值显著低于偏头痛患者以及两种头痛疾病患者。在比较所有组时，除偏头痛女性外，Km无显著差异，偏头痛女性的Km值低于对照女性。与偏头痛相比，丛集性头痛的热稳定性显著更高，且与对照组相比，两种头痛疾病的热稳定性均显著更高。每天吸烟五支或更多的吸烟者的Vmax值显著低于吸烟较少或不吸烟的人，但Km和热稳定性值相似。丛集性头痛和偏头痛患者血小板MAO的最大速度低和热稳定性高的结果表明其代表了体质上不同的酶特性。
