血小板单胺氧化酶活性与头痛
Platelet monoamine oxidase activity and headache.
作者信息
Glover V, Peatfield R, Zammit-Pace R, Littlewood J, Gawel M, Rose F C, Sandler M
出版信息
J Neurol Neurosurg Psychiatry. 1981 Sep;44(9):786-90. doi: 10.1136/jnnp.44.9.786.
Abstract
Mean platelet monoamine oxidase activity was reduced compared with control values in groups of headache-free male (but not female) patients suffering from classical migraine and from tension headache. Mean activity in male cluster patients, headache free, both during acute and quiescent phases of their illness, was also notably reduced. Retesting some migraine subjects after up to four years, showed that low activity may be a persistent feature: the correlation coefficient for repeated assays was 0.91 (p less than 0.01). There was no relationship between platelet monoamine oxidase activity and history of dietary migraine. A subgroup of headache patients with permanently low monoamine oxidase activity values may have been defined.
摘要
与对照组相比，患有典型偏头痛和紧张性头痛的无头痛男性（而非女性）患者组的平均血小板单胺氧化酶活性降低。无头痛的男性丛集性头痛患者在疾病的急性期和静止期的平均活性也显著降低。对一些偏头痛患者进行长达四年的重新检测，结果表明低活性可能是一个持续的特征：重复检测的相关系数为0.91（p小于0.01）。血小板单胺氧化酶活性与饮食性偏头痛病史之间没有关系。可能已经定义了一个单胺氧化酶活性值永久偏低的头痛患者亚组。
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