Boel J, Andersen L B, Rasmussen B, Hansen S H, Døssing M
Clin Pharmacol Ther. 1984 Jul;36(1):121-6. doi: 10.1038/clpt.1984.149.
Physical fitness, as expressed by maximal oxygen uptake (Vo2max), was measured in 14 subjects before and during physical education consisting of 4 to 8 hr of daily physical training. Mean pulse rate during training was 115 bpm. After 3 mo of physical training, Vo2max increased a mean 6% (range -5% to +23%). Corresponding mean increases in hepatic drug metabolism, as expressed by the metabolism of the model drugs antipyrine and aminopyrine, were 12% (range -12% to +59%) and 13% (range -21% to +47%). Changes in the two groups were still present 6 mo after physical education. There was only a moderately close but nonetheless significant correlation (r = 0.7) between the extent of change in Vo2max and the corresponding relative change in antipyrine metabolism during the 3-mo period of this investigation. The correlation between oxygen uptake and aminopyrine metabolism (r = 0.6) was slightly less and was not significant. Improved physical fitness associated with enhanced drug metabolism may lead to changes in drug efficacy and drug toxicity that may be clinically important in the case of drugs with low therapeutic indices.
对14名受试者在进行为期4至8小时的每日体育训练的体育课之前和期间，测量了以最大摄氧量（Vo2max）表示的体能。训练期间的平均脉搏率为115次/分钟。经过3个月的体育训练后，Vo2max平均增加了6%（范围为-5%至+23%）。以模型药物安替比林和氨基比林的代谢表示的肝脏药物代谢相应的平均增加分别为12%（范围为-12%至+59%）和13%（范围为-21%至+47%）。体育课后6个月，两组的变化仍然存在。在本研究的3个月期间，Vo2max的变化程度与安替比林代谢的相应相对变化之间仅存在中等程度的密切但仍显著的相关性（r = 0.7）。摄氧量与氨基比林代谢之间的相关性（r = 0.6）略低且不显著。与药物代谢增强相关的体能改善可能会导致药物疗效和药物毒性的变化，这在治疗指数较低的药物情况下可能具有临床重要性。
