基于生物电阻抗分析的个体化茶碱给药
Individual theophylline dosing based on bioelectrical impedance analysis.
作者信息
Sidhu J S, Triggs E J, Charles B G, Smithurst B A
机构信息
Department of Pharmacy, University of Queensland, Australia.
出版信息
Br J Clin Pharmacol. 1993 Jun;35(6):657-60. doi: 10.1111/j.1365-2125.1993.tb04198.x.
The role of bioelectrical impedance (BI) analysis in determining slow-release theophylline dosage was evaluated in fifteen healthy subjects given a standard 200 mg dose. Reactance and l/resistance were identified as the most significant predictors of pre-dose, steady-state theophylline concentrations (Css,pre). Compared with doses based on body weight (8.8 mg kg-1 day-1), theophylline doses determined by BI analysis (9.6 +/- 2.4 mg kg-1 day-1) resulted in less biased (mean prediction error = 0.6 vs 1.4) though slightly less precise (mean squared error = 7.1 vs 6.3) Css,pre values. These differences were statistically insignificant (P > 0.05).
在15名接受标准200毫克剂量的健康受试者中，评估了生物电阻抗（BI）分析在确定缓释茶碱剂量方面的作用。电抗和电阻倒数被确定为给药前稳态茶碱浓度（Css,pre）的最显著预测因子。与基于体重的剂量（8.8毫克/千克/天）相比，通过BI分析确定的茶碱剂量（9.6±2.4毫克/千克/天）导致Css,pre值的偏差较小（平均预测误差=0.6对1.4），尽管精度略低（均方误差=7.1对6.3）。这些差异无统计学意义（P>0.05）。
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