Beermann B, Edelstam C
Eur Heart J. 1984 Apr;5(4):338-42. doi: 10.1093/oxfordjournals.eurheartj.a061661.
Tizolemide, an alkaline sulphonamide diuretic, was given i.v. in one dose and orally during one week to eight patients with compensated cardiac failure. They had essentially normal glomerular filtration rate but reduced renal plasma flow. Tizolemide was almost completely absorbed from the gastrointestinal tract. The drug was mainly eliminated via tubular secretion. Renal clearance of the drug was much lower than in healthy subjects because of low renal plasma flow. As a consequence plasma half-life was prolonged considerably in some patients. It was concluded that drugs with mainly tubular renal elimination may have a reduced elimination rate in patients with cardiac diseases despite normal glomerular filtration rate.
替唑米胺是一种碱性磺酰胺类利尿剂，对8例代偿性心力衰竭患者静脉注射单剂量，并在一周内口服给药。这些患者的肾小球滤过率基本正常，但肾血浆流量降低。替唑米胺几乎完全从胃肠道吸收。该药物主要通过肾小管分泌消除。由于肾血浆流量低，该药物的肾清除率远低于健康受试者。因此，部分患者的血浆半衰期显著延长。得出的结论是，主要经肾脏肾小管消除的药物，在患有心脏病的患者中，尽管肾小球滤过率正常，但其消除率可能会降低。
