Dodion L, Willems J L
Eur J Clin Pharmacol. 1986;31 Suppl:49-51. doi: 10.1007/BF00541467.
The plasma concentration of torasemide was determined as a function of time in 8 patients with impaired renal function (creatinine clearance less than or equal to 25 ml/min). The elimination half-life (1.3 to 3.8 h), the volume of distribution (0.12 to 0.29 l/kg), and the total body clearance (0.02 to 0.10 l/kg X h) were similar to those observed in normal volunteers.
在8名肾功能受损（肌酐清除率小于或等于25 ml/min）的患者中，测定了托拉塞米的血浆浓度随时间的变化情况。消除半衰期（1.3至3.8小时）、分布容积（0.12至0.29 l/kg）和全身清除率（0.02至0.10 l/kg×小时）与正常志愿者中观察到的情况相似。
