Determination of ribonuclease activity in the serum of ovarian carcinoma patients.

Increased serum ribonuclease activity represents a phenomenon of ovarian carcinoma. We have developed a convenient sensitive and reproducible assay system to determine the ribonuclease activity in human serum. The influence of various factors and conditions like storage, pH, salt, heparin, and the accuracy of the determination of HSRA was investigated.