Otero M J, Garcia M J, Barrueco M, Dominguez-Gil A, Gomez F, Portugal Alvarez J
Eur J Clin Pharmacol. 1984;26(3):389-92. doi: 10.1007/BF00548772.
The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pleural fluid in all cases was 2-3 fold longer than from serum, which shows a difference between the kinetic elimination processes of the antibiotic from the two fluids. The slow elimination of cefoxitin from pleural fluid facilitates its accumulation in this compartment during a multiple dosage regimen.
在6名健康志愿者和5名胸腔积液患者中，静脉输注单剂量30mg/kg头孢西丁后，对其药代动力学进行了研究。采用微生物学方法测定血清和胸腔积液中头孢西丁的浓度。在所有病例中，抗生素在胸腔积液中的消除半衰期比血清中的长2至3倍，这表明抗生素在两种液体中的动力学消除过程存在差异。在多剂量给药方案中，头孢西丁从胸腔积液中缓慢消除有利于其在该腔室中蓄积。
