Kobayashi Y, Kawashima S
Exp Gerontol. 1984;19(2):107-13. doi: 10.1016/0531-5565(84)90013-5.
The changes of water intake, urinary volume, ratio of the water intake to the urinary output (water turnover rate) and urinary concentrations of sodium, potassium and chloride ions were investigated in male rats of the inbred Wistar/Tw strain during aging. Marked increase of the water intake, the urinary output and the water turnover rate as well as marked decrease of the urinary electrolyte concentrations were observed at the age of over 16 months. First signs of increase in the water intake and the water turnover rate were observed at the age of 12-13 months, but the initial reduction of urinary electrolyte concentrations was detected as early as at 7-9 months of age.
在近交系Wistar/Tw雄性大鼠衰老过程中，研究了其饮水量、尿量、进水与尿量之比（水周转率）以及尿中钠、钾和氯离子浓度的变化。在16个月以上的大鼠中，观察到饮水量、尿量和水周转率显著增加，同时尿电解质浓度显著降低。在12 - 13个月龄时观察到饮水量和水周转率增加的最初迹象，但早在7 - 9个月龄时就检测到尿电解质浓度开始降低。
