Botta R M, Donatelli M, Bucalo M L, Bellomonte M L, Bompiani G D
Eur J Obstet Gynecol Reprod Biol. 1984 Mar;16(6):393-401. doi: 10.1016/0028-2243(84)90020-0.
Fifteen insulin-dependent diabetic (White's class B-C) and 10 healthy pregnant women were examined from the 12th to the 36th wk. Every 4 wk, a blood sample was drawn to determine total estriol, progesterone, placental lactogen and prolactin. Throughout the pregnancy, total estriol and progesterone in diabetic and non-diabetic women are very similar. On the contrary, the PRL levels are constantly lower in diabetic pregnant women, even though the difference is statistically significant only for the 24th wk determination. The hPL level is instead significantly lower in diabetic pregnant women at the 12th, 20th, 24th, 32nd and 36th wk. A negative correlation exists between the hPL value and the mean blood glucose level, performed the same day as the hormonal test. This correlation is statistically significant at the 12th, 16th, 20th, 28th and 36th wk. No significant difference is found between the two groups examined for the delivery week, the placental weight, the birth weight and the fetal body weight index. To conclude, while estriol and progesterone are not affected by the higher variability of glucose levels during pregnancy in diabetics, compared to normals, hPL and perhaps also PRL may be influenced by the mild hyperglycemia consequent to diabetes.
对15名胰岛素依赖型糖尿病患者（怀特分类B - C级）和10名健康孕妇在孕12周到36周期间进行了检查。每4周采集一次血样，以测定总雌三醇、孕酮、胎盘催乳素和催乳素。在整个孕期，糖尿病患者和非糖尿病患者的总雌三醇和孕酮水平非常相似。相反，糖尿病孕妇的催乳素水平持续较低，尽管仅在第24周测定时差异具有统计学意义。而在孕12周、20周、24周、32周和36周时，糖尿病孕妇的人胎盘催乳素水平显著较低。在进行激素检测的同一天，人胎盘催乳素值与平均血糖水平之间存在负相关。这种相关性在第12周、16周、20周、28周和36周时具有统计学意义。在分娩周、胎盘重量、出生体重和胎儿体重指数方面，两组之间未发现显著差异。总之，与正常人相比，糖尿病患者孕期血糖水平的较高变异性虽不影响雌三醇和孕酮，但人胎盘催乳素以及可能还有催乳素可能会受到糖尿病所致轻度高血糖的影响。
