将氯喹与阿司匹林同时给家兔注射时氯喹的吸附、分布及消除情况。

Adsorption, distribution and elimination of chloroquine in the presence of aspirin when administered into rabbits.

作者信息

Adelusi S A

出版信息

Gen Pharmacol. 1984;15(3):259-61. doi: 10.1016/0306-3623(84)90171-x.

Abstract

The absorption, distribution and elimination of chloroquine were studied in rabbits upon oral administration of chloroquine with aspirin. The time-lag, half-life of absorption and absorption rate constant obtained in both cases were significantly different (P less than 0.01) whereas the half-life of elimination and the elimination rate constant were not significantly different (P greater than 0.01). The results showed that absorption was delayed when aspirin was simultaneously administered with chloroquine but the distribution and elimination of chloroquine were not affected by the presence of aspirin.

摘要

在给兔子口服氯喹和阿司匹林后，研究了氯喹的吸收、分布和消除情况。两种情况下获得的时滞、吸收半衰期和吸收速率常数均有显著差异（P小于0.01），而消除半衰期和消除速率常数无显著差异（P大于0.01）。结果表明，当阿司匹林与氯喹同时给药时，氯喹的吸收延迟，但阿司匹林的存在不影响氯喹的分布和消除。