阿司匹林、对乙酰氨基酚和安乃近对氯喹药代动力学的影响。
The effect of aspirin, paracetamol and analgin on pharmacokinetics of chloroquine.
作者信息
Raina R K, Bano G, Amla V, Kapoor V, Gupta K L
机构信息
Department of Pharmacology and Therapeutics, Government Medical College, Jammu, Tawi.
出版信息
Indian J Physiol Pharmacol. 1993 Jul;37(3):229-31.
PMID:8276502
Abstract
The effect of Aspirin, paracetamol and analgin on the kinetic profile of a single oral dose of chloroquine was studied in 8 healthy subjects. Aspirin did not alter the kinetic parameters of chloroquine whereas paracetamol and analgin significantly enhanced the Cmax and AUC0-alpha of chloroquine (P < 0.01, < 0.05 respectively).
摘要
在8名健康受试者中研究了阿司匹林、对乙酰氨基酚和安乃近对单次口服氯喹动力学特征的影响。阿司匹林未改变氯喹的动力学参数，而对乙酰氨基酚和安乃近显著提高了氯喹的Cmax和AUC0-α（分别为P < 0.01，< 0.05）。
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