2-Propylthiouracil does not replace glutathione for the glutathione transferases.

2-Propylthiouracil has been reported as replacing glutathione as a substrate for the glutathione transferases of rat liver. This observation has been examined with several homogeneous glutathione transferases that were prepared from human and rat liver by different methods in three laboratories. No evidence was obtained for 2-propylthiouracil as a substrate for glutathione transferase in the several reactions tested.