De Boer W G, Ma J, Rees J W, Nayman J
Histopathology. 1981 May;5(3):295-303. doi: 10.1111/j.1365-2559.1981.tb01788.x.
This study demonstrates the presence of three antigens in glandular metaplasia occurring in patients with cholecystitis and cholelithiasis: specifically carcinoembryonic antigen (CEA), large intestinal mucin antigen (LIMA) and small intestinal mucin antigen (SIMA). These antigens could not be detected in normal gall bladder mucosa or in squamous metaplasia of the gall bladder. The occurrence of the three intestine-associated antigens in three carcinomas was irregular. In one mucinous carcinoma, only SIMA could be demonstrated. In one adenocarcinoma, SIMA was present in small areas of mucinous change, whilst CEA was present in the non-mucinous malignant tissue. In a mixed mucinous and non-mucinous adenocarcinoma with widespread dissemination, the three antigens were present both in the primary tumour and the metastases. These observations suggest that all forms of glandular metaplasia of the gall bladder are intestinal in nature and at least a proportion of gall bladder carcinomas are of an intestinal type. Finally they provide further immunological evidence that glandular metaplasia of the gall bladder should be considered a pre-malignant condition.
具体为癌胚抗原（CEA）、大肠粘蛋白抗原（LIMA）和小肠粘蛋白抗原（SIMA）。在正常胆囊黏膜或胆囊鳞状化生中未检测到这些抗原。三种与肠道相关的抗原在三种癌中的出现情况并不规律。在一例黏液癌中，仅能证实存在SIMA。在一例腺癌中，SIMA存在于黏液样改变的小区域，而CEA存在于非黏液性恶性组织中。在一例广泛播散的黏液性和非黏液性腺癌混合病例中，原发肿瘤和转移灶中均存在这三种抗原。这些观察结果表明，胆囊的所有形式的腺化生本质上都是肠型的，并且至少一部分胆囊癌是肠型的。最后，它们提供了进一步的免疫学证据，表明胆囊腺化生应被视为一种癌前状态。
