Gonzalez E, Momtaz-T K, Freedman S
J Am Acad Dermatol. 1984 Jun;10(6):958-61. doi: 10.1016/s0190-9622(84)80312-6.
Ten patients with generalized lichen planus were treated with oral 8-methoxypsoralen photochemotherapy (PUVA) in a bilateral comparison study. Five patients (50%) cleared completely on both sides and required no maintenance treatment after a follow-up of up to 4 years. Three other patients (30%) improved at least 50% of their previous involvement. Most of the patients experienced symptomatic improvement of the treated side by the second week of the treatment. Two patients reacted adversely and exacerbated while receiving treatment to one side of the body. While preliminary, this bilateral comparison study demonstrates that PUVA is an effective therapy for generalized, symptomatic lichen planus and suggests that maintenance therapy might not be required once complete clearance is attained. Caution should be exercised, however, since some patients might develop an exacerbation of their disease with PUVA.
在一项双侧对照研究中，对10例泛发性扁平苔藓患者采用口服8-甲氧基补骨脂素光化学疗法（PUVA）进行治疗。5例患者（50%）双侧皮损完全清除，随访长达4年无需维持治疗。另外3例患者（30%）病情改善至少达先前受累程度的50%。大多数患者在治疗的第二周时，治疗侧的症状即有改善。2例患者在对身体一侧进行治疗时出现不良反应且病情加重。虽然这项双侧对照研究尚属初步研究，但它表明PUVA是治疗泛发性、有症状扁平苔藓的有效疗法，并提示一旦皮损完全清除，可能无需维持治疗。然而，应谨慎使用，因为有些患者使用PUVA可能会导致病情加重。
