Lundquist G, Forsgren H, Gajecki M, Emtestam L
Department of Oral Surgery, Karolinska Institute, Huddinge, Sweden.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 May;79(5):554-8. doi: 10.1016/s1079-2104(05)80094-0.
Photochemotherapy with 8-methoxypsoralen and long-wave ultraviolet light (PUVA) has become a useful alternative in dermatologic therapy. PUVA therapy has been successfully used in the treatment of severe psoriasis and cutaneous lichen planus. The aim of this investigation was to use PUVA in the treatment of oral lichen planus (OLP). Eighteen patients with long-standing, bilateral, and severe OLP of the buccal mucosa participated in the investigation. A dose of 0.6 mg/kg 8-methoxypsoralen was administered orally 2 hours before long-wave ultraviolet light irradiation was done. The patients were randomly assigned to treatment of the left or right side of the buccal mucosa. The irradiation therapy was given 12 times at intervals of 2 to 3 days, and the patients received a total average dosage of 16.5 J/cm2. The results showed that 13 treated sites compared with six control sites responded significantly favorable to PUVA therapy. Two patients dropped out because of side effects that were similar to those seen after whole-body irradiation PUVA treatment. The follow up times was 12 months. The conclusion of this study is that PUVA seems to be effective in the treatment of OLP and should be considered in severe cases of OLP.
8-甲氧基补骨脂素与长波紫外线光化学疗法（PUVA）已成为皮肤科治疗中一种有用的替代方法。PUVA疗法已成功用于治疗重度银屑病和皮肤扁平苔藓。本研究的目的是将PUVA用于治疗口腔扁平苔藓（OLP）。18例患有颊黏膜长期、双侧且重度OLP的患者参与了该研究。在进行长波紫外线照射前2小时口服0.6mg/kg的8-甲氧基补骨脂素。患者被随机分配接受颊黏膜左侧或右侧的治疗。照射治疗每隔2至3天进行12次，患者平均总剂量为16.5J/cm²。结果显示，与6个对照部位相比，13个治疗部位对PUVA疗法反应显著良好。2例患者因出现与全身照射PUVA治疗后相似的副作用而退出。随访时间为12个月。本研究的结论是，PUVA似乎对OLP治疗有效，在OLP的重症病例中应予以考虑。
