帕金森病运动功能波动期间认知表现和情感唤醒状态的改变。
Alterations in cognitive performance and affect-arousal state during fluctuations in motor function in Parkinson's disease.
作者信息
Brown R G, Marsden C D, Quinn N, Wyke M A
出版信息
J Neurol Neurosurg Psychiatry. 1984 May;47(5):454-65. doi: 10.1136/jnnp.47.5.454.
Abstract
Sixteen patients with idiopathic Parkinson's disease were selected who were all showing severe fluctuations in motor function ("on-off" phenomenon). Measures of cognitive function and of subjective affect/arousal state were taken on two occasions, once when "on" and once when "off". Twenty-five matched normal controls were also assessed on the same measures. Results revealed, on the average, a drop in cognitive function plus an adverse swing in affect/arousal state, in the patient group in the "off" condition, compared to the levels when "on". Analysis of the data suggested that the main factor associated with cognitive function when "off" was not the severity of disability but the level of affect/arousal. The fluctuations in cognitive function found tended to be mild relative to the severe changes in motor ability, and were present in only a proportion of patients.
摘要
选取了16例特发性帕金森病患者，他们均表现出严重的运动功能波动（“开-关”现象）。认知功能及主观情感/觉醒状态的测量分两次进行，一次在“开”期，一次在“关”期。还对25名匹配的正常对照者进行了相同测量。结果显示，与“开”期水平相比，患者组在“关”期时认知功能平均下降，情感/觉醒状态出现不利波动。数据分析表明，与“关”期认知功能相关的主要因素不是残疾严重程度，而是情感/觉醒水平。所发现的认知功能波动相对于运动能力的严重变化而言往往较为轻微，且仅在部分患者中出现。
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