Matison R, Mayeux R, Rosen J, Fahn S
Neurology. 1982 May;32(5):567-70. doi: 10.1212/wnl.32.5.567.
Articulatory disturbances are frequently described in Parkinson disease, but language disorders are not. We have occasionally encountered parkinsonian patients with word-finding difficulty unrelated to memory loss, intellectual impairment, or dysarthria. To examine this, 22 medically stable parkinsonian patients were given the vocabulary subtest of the WAIS, the Boston Naming Test, measures of verbal fluency, and sentence repetition. Signs and symptoms of parkinsonism were rated. WAIS vocabulary subtest scores were above the mean for normal aged subjects, but confrontation naming was one standard deviation below norms for age and education. Naming was facilitated by cues in most patients. Only sentence repetition correlated with dysarthria. Category naming was impaired and correlated significantly with the severity of parkinsonism, especially bradykinesia. This suggests that a type of anomia may occur in Parkinson disease. it shares the clinical characteristics of the "tip-of-the-tongue" phenomenon and "word production anomia" seen in some aphasics.
帕金森病常伴有构音障碍,但语言障碍却不常见。我们偶尔会遇到一些帕金森病患者,他们存在与记忆力减退、智力障碍或构音障碍无关的找词困难。为了对此进行研究,我们对22名病情稳定的帕金森病患者进行了韦氏成人智力量表(WAIS)的词汇分测验、波士顿命名测验、言语流畅性测量以及句子复述测试。同时对帕金森病的体征和症状进行了评分。WAIS词汇分测验的得分高于正常老年人的平均分,但面对面对物体命名的得分比同年龄和受教育程度人群的常模低一个标准差。大多数患者在提示下命名能力有所提高。只有句子复述与构音障碍相关。类别命名受损,且与帕金森病的严重程度显著相关,尤其是运动迟缓。这表明帕金森病可能会出现一种类型的命名性失语。它具有一些失语症患者中所见的“舌尖现象”和“词生成性命名性失语”的临床特征。