Muramoto O, Sugishita M, Ando K
J Neurol Neurosurg Psychiatry. 1984 May;47(5):485-91. doi: 10.1136/jnnp.47.5.485.
Subcutaneous or intravenous administration of physostigmine improved the copying of geometric figures in three out of six patients with presumed Alzheimer's disease who showed a remarkable constructional disturbance. This improvement reached its maximum 30 to 60 minutes after the physostigmine administration. These results not only provide further evidence supporting the hypothesis that central cholinergic potentiation ameliorates some of the impairments of Alzheimer's disease, but implicate a possible important role of the cholinergic system in the integration of constructional praxis.
对六名疑似患有阿尔茨海默病且存在明显结构障碍的患者中的三名，皮下或静脉注射毒扁豆碱改善了其临摹几何图形的能力。这种改善在注射毒扁豆碱后30至60分钟达到最大程度。这些结果不仅为支持中枢胆碱能增强可改善阿尔茨海默病某些损伤这一假说提供了进一步证据，还表明胆碱能系统在结构实践整合中可能发挥重要作用。
