Peters B H, Levin H S
Arch Neurol. 1977 Apr;34(4):215-9. doi: 10.1001/archneur.1977.00500160029004.
Central anticholinergic agents (eg, scopolamine) are known to produce transient memory deficits in human and animal subjects. Damage to the limbic system frequently results from herpes simplex encephalitis (HSE) and produces a memory deficit. If this deficit is due to limbic cholinergic pathway destruction, it might improve with central cholinergic agonists (eg, physostigmine). In a doubleblind study over a three-week period, we compared memory performance on three days after 0.8-mg subcutaneous physostigmine therapy (three sessions) to baseline performance and that obtained in three randomly interspersed control sessions. Serial assessment of memory by the Selective Reminding Test showed reproducible enhancement of long-term storage and retrieval with physostigmine treatment. Performance after control injections did not exceed baseline levels. Our findings encourage the hypothesis that cholinergic mechanisms subserve memory and that their pharmacological potentiation might favorable influence some amnesic conditions.
中枢抗胆碱能药物（如东莨菪碱）已知会在人类和动物受试者中产生短暂的记忆缺陷。单纯疱疹性脑炎（HSE）经常导致边缘系统受损，并产生记忆缺陷。如果这种缺陷是由于边缘胆碱能通路破坏所致，那么使用中枢胆碱能激动剂（如毒扁豆碱）可能会有所改善。在一项为期三周的双盲研究中，我们将皮下注射0.8毫克毒扁豆碱治疗（三个疗程）后三天的记忆表现与基线表现以及在三个随机穿插的对照疗程中获得的表现进行了比较。通过选择性提醒测试对记忆进行的系列评估显示，毒扁豆碱治疗可使长期存储和检索能力得到可重复的增强。对照注射后的表现未超过基线水平。我们的研究结果支持这样一种假设，即胆碱能机制有助于记忆，并且其药理学增强作用可能会对某些失忆状况产生有利影响。
