Seidenfeld J J, Eskelson C D, Toyoshima J M
Life Sci. 1984 Jul 9;35(2):191-8. doi: 10.1016/0024-3205(84)90139-5.
In order to examine the effects of paraquat on pulmonary lipid metabolism rabbits were exposed to double distilled water by aerosol, or 250 mg paraquat in double distilled water. One hour prior to sacrifice, a group of rabbits were injected with [2-14C]-acetate. The levels of phospholipids, fatty acids, cholesterol, and triglycerides were determined as were their 14C-contents in the lung, bronchoalveolar lavage fluid, serum, and liver. The serum of paraquat-exposed animals contained significantly increased levels of phospholipids, cholesterol, and triglycerides. Liver, lung, and bronchoalveolar lavage contained less than or equal to control levels of phospholipids, cholesterol, and triglycerides. Percent of palmitate in the hepatic fatty acid profile was slightly increased in liver but not in lung. The source of the increased lipids in the serum is unknown.
为了研究百草枯对肺脂质代谢的影响，将兔子通过气雾剂暴露于双蒸水或双蒸水中的250毫克百草枯。在处死前一小时，给一组兔子注射[2-¹⁴C]-乙酸盐。测定了肺、支气管肺泡灌洗液、血清和肝脏中磷脂、脂肪酸、胆固醇和甘油三酯的水平及其¹⁴C含量。暴露于百草枯的动物血清中磷脂、胆固醇和甘油三酯水平显著升高。肝脏、肺和支气管肺泡灌洗液中磷脂、胆固醇和甘油三酯水平低于或等于对照水平。肝脏脂肪酸谱中棕榈酸的百分比略有增加，但肺中未增加。血清中脂质增加的来源尚不清楚。
