Hassan R A, Afzal M, Ali M, Gubler C J
Department of Biochemistry, Faculty of Science, Kuwait University.
Ecotoxicol Environ Saf. 1989 Feb;17(1):47-58. doi: 10.1016/0147-6513(89)90008-0.
Rabbits were injected intraperitoneally with 3, 6, or 12 mg of paraquat/kg/day for a period of 3, 7, or 14 days. Rabbits receiving 3 or 6 mg of paraquat/kg/day showed a significant loss of body weight at 7 days of the treatment. Liver, kidney, heart, and lungs demonstrated a significant decrease in their weights in the first 3 days of paraquat treatment. A decrease in total lipids, total triglycerides, and total cholesterol of both liver and kidney was observed. This decrease was accompanied by a significant increase in plasma total triglycerides and total cholesterol at 7 days of paraquat treatment. The ratio of cholesterol to cholesterol esters in liver decreased after 3 days of paraquat treatment after which it showed a consistent increase until the 14th day of the paraquat treatment. In kidney, this ratio increased for up to 7 days of paraquat treatment followed by a decrease at the 14th day. These results indicate, contrary to earlier reports, that rabbits are susceptible to paraquat toxicity.
给兔子腹腔注射百草枯，剂量为3、6或12毫克/千克/天，持续3、7或14天。接受3或6毫克/千克/天百草枯注射的兔子在治疗7天时体重显著下降。在百草枯治疗的前3天，肝脏、肾脏、心脏和肺的重量显著减轻。观察到肝脏和肾脏的总脂质、总甘油三酯和总胆固醇均减少。这种减少伴随着百草枯治疗7天时血浆总甘油三酯和总胆固醇的显著增加。百草枯治疗3天后，肝脏中胆固醇与胆固醇酯的比例下降，此后直至百草枯治疗第14天一直持续增加。在肾脏中，该比例在百草枯治疗7天时一直增加，随后在第14天下降。这些结果表明，与早期报告相反，兔子易受百草枯毒性影响。
