[Immunoelectrophoretic evaluation of blood proteins in persons chronically exposed to manganese].

Studies involved 69 men occupationally exposed--on average for 9-4 years--to manganese dusts and vapours at 0.00013 mg/l-0.00449 mg/l concentrations and trace amounts of ferrum and titanium. The control group consisted of 41 men unexposed to toxic substances. Those chronically exposed to manganese exhibited changes in serum albumins immunoelectrophoretic picture in form of much weaker saturation of IgA and IgM arches, transferrin and ceruloplasmin, and markedly increased saturation of IgG arches. Those changes may result from toxic effects of manganese upon liver cells.