Bencko V, Wagner V, Wagnerová M, Reichrtová E
J Hyg Epidemiol Microbiol Immunol. 1983;27(4):387-94.
Immune reactions elicited in the sera of individuals exposed to nickel and cobalt were assessed by changes in the concentration of serum immunoglobulins IgG, IgA and IgM and serum proteins alpha 2 macroglobulin (A2M), transferrin (TRF), alpha 1-antitrypsin (A1AT), ceruloplasmin (CPL) and lysozyme (LYS). Examinations were carried out in workers occupationally exposed to Ni (38 individuals) or Co (35 individuals) and in groups of non-occupationally exposed children living in areas with a different degree of air pollution from a nearby source of Ni and Co emissions (one group was made up of 54 exposed children, the other one of 64 "less exposed" children of the same age). Groups of non-exposed controls were represented by a group of 42 male adults matched by age and by a group of 48 children from a non-polluted area. Significantly increased average values were obtained for IgG, IgA and IgM in group of workers exposed to Ni, for IgA in workers exposed to Co and for A1AT, A2M, CPL and LYS in both groups of occupationally exposed adults (p less than 0.001 - p less than 0.005). Among non-occupationally exposed children the group of the most exposed had significantly elevated average values for A2M and A1AT which were higher than those recorded in groups of "less exposed" and control children (p less than 0.02 and p less than 0.05, respectively). The biomedical importance of these findings is discussed in detail.
通过检测血清免疫球蛋白IgG、IgA和IgM以及血清蛋白α2巨球蛋白（A2M）、转铁蛋白（TRF）、α1抗胰蛋白酶（A1AT）、铜蓝蛋白（CPL）和溶菌酶（LYS）的浓度变化，评估接触镍和钴的个体血清中引发的免疫反应。对职业接触镍的工人（38名个体）或钴的工人（35名个体）以及居住在来自附近镍和钴排放源空气污染程度不同地区的非职业接触儿童组（一组由54名接触儿童组成，另一组由64名同龄的“较少接触”儿童组成）进行了检测。未接触对照组由一组42名年龄匹配的男性成年人和一组来自无污染地区的48名儿童组成。接触镍的工人组中IgG、IgA和IgM的平均值显著升高，接触钴的工人组中IgA的平均值显著升高，两组职业接触成年人中A1AT、A2M、CPL和LYS的平均值显著升高（p＜0.001 - p＜0.005）。在非职业接触儿童中，接触程度最高的组中A2M和A1AT的平均值显著升高，高于“较少接触”组和对照组儿童记录的值（分别为p＜0.02和p＜0.05）。详细讨论了这些发现的生物医学重要性。
