Chiba T, Boles E T, Staples G
Nihon Geka Gakkai Zasshi. 1984 Jan;85(1):49-55.
Partial splenectomy is often preferred to total splenectomy as a method to prevent serious post-operative sepsis. However, most of the previous researches on spleen function following partial splenectomy have failed to provide accurate data on the minimum increase of residual spleen in weight necessary for protection against postoperative sepsis. This is not only to the lack of appropriate model but also to the negligence of the effects of spleen regeneration after partial splenectomy. To produce an accurate model for partial splenectomies, and to know how the spleen regenerates following partial resection, about 500 rats underwent partial splenectomies. From these experiments, the following results were obtained. These partial splenectomies based on length of the spleen were satisfactory models as partial splenectomy. Absolute volume of regenerated spleen was finally almost the same in every model. However, the less the remnant spleen was the longer period was necessary until the spleen regeneration completed.
作为预防严重术后脓毒症的一种方法，部分脾切除术通常比全脾切除术更受青睐。然而，以往大多数关于部分脾切除术后脾功能的研究都未能提供准确数据，说明为预防术后脓毒症，残余脾脏重量至少需要增加多少。这不仅是因为缺乏合适的模型，还因为部分脾切除术后对脾再生效应的忽视。为了建立准确的部分脾切除术模型，并了解部分切除术后脾脏如何再生，约500只大鼠接受了部分脾切除术。从这些实验中，得到了以下结果。这些基于脾脏长度的部分脾切除术是满意的部分脾切除模型。每个模型中再生脾的绝对体积最终几乎相同。然而，残余脾脏越少，脾脏再生完成所需的时间就越长。
