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[脾脏微粒自体再植术——一种成熟的手术?一种观点]

[Autologous replantation of spleen particles--an established procedure? An opinion].

作者信息

Hohenberger W, Haupt W, Kalden J R, Simon M, Mahlstedt J

出版信息

Chirurg. 1985 Oct;56(10):659-62.

PMID:4075880
Abstract

Autologous splenic replantation after splenectomy for trauma is generally recommended in order to prevent postsplenectomy sepsis. Several aspects, however, make this method uncertain: The extent of splenosis induced is not to be predicted. Even if the whole spleen is replanted, the resulting mass may not exceed splenosis, which sometimes develops spontaneously after sole splenectomy. But patients with extended splenic regenerates do not differ from those without any splenosis, considering various immunologic parameters. Postoperative complications after splenic replantation (abscess, intestinal occlusion) are possible, although they may be rare. Fatal cases of postsplenectomy sepsis despite massive splenosis are known. The most important reasons apparently are the altered vascularity and scarring in splenic regenerates. There is no specific test for immunological splenic function. Therefore there is no test to judge the success of replantation, too. Overall, the preservation of the spleen and the vaccination of splenectomized individuals are the most important surgical intentions.

摘要

为预防脾切除术后败血症,一般建议对因创伤行脾切除术的患者进行自体脾移植。然而,有几个方面使得这种方法存在不确定性:诱导产生的脾组织异位的范围难以预测。即使整个脾脏都被移植,所形成的组织块可能也不会超过脾组织异位,而脾组织异位有时在单纯脾切除术后会自发出现。但是,考虑到各种免疫参数,脾再生组织扩展的患者与没有任何脾组织异位的患者并无差异。脾移植术后可能会出现并发症(脓肿、肠梗阻),尽管可能较为罕见。已知尽管存在大量脾组织异位,但仍有脾切除术后败血症的致死病例。显然,最重要的原因是脾再生组织中血管改变和瘢痕形成。目前尚无针对脾脏免疫功能的特异性检测方法。因此,也没有检测来判断移植是否成功。总体而言,保留脾脏以及对脾切除患者进行疫苗接种是最重要的手术目的。

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