Capasso O, Tajana G, Cancedda R
Mol Cell Biol. 1984 Jun;4(6):1163-8. doi: 10.1128/mcb.4.6.1163-1168.1984.
The synthesis of a new low-molecular-weight collagen by cultured chicken embryo chondrocytes has been recently demonstrated (Capasso et al., Exp. Cell Res. 142:197-206, 1982; Gibson et al., J. Cell Biol. 93:767-774, 1982; Schmid and Conrad, J. Biol. Chem. 257:12444-12450, 1982). In this paper we report results on the location of chondrocytes synthesizing this new collagen (64K collagen) in the developing chicken embryo. The 64K collagen is synthesized in very large amounts by cells concentrated at the diaphysis of 9-day-old and at the epiphysis of 17-day-old embryo tibiae. These regions are characterized by a remodeling of the cartilage matrix leading to the replacement of the cartilage with bone tissue; therefore, this collagen appears to be a marker of a specific developmental stage of chondrocytes. The origin of cells competent for the synthesis of the 64K collagen is also discussed.
最近已证实培养的鸡胚软骨细胞能合成一种新的低分子量胶原蛋白（卡帕索等人，《实验细胞研究》142:197 - 206，1982；吉布森等人，《细胞生物学杂志》93:767 - 774，1982；施密德和康拉德，《生物化学杂志》257:12444 - 12450，1982）。在本文中，我们报告了关于发育中的鸡胚中合成这种新胶原蛋白（64K胶原蛋白）的软骨细胞位置的研究结果。9日龄胚胎胫骨骨干和17日龄胚胎胫骨骨骺处聚集的细胞大量合成64K胶原蛋白。这些区域的特征是软骨基质重塑，导致软骨被骨组织替代；因此，这种胶原蛋白似乎是软骨细胞特定发育阶段的一个标志。本文还讨论了能够合成64K胶原蛋白的细胞的起源。
