Hughey M J
Obstet Gynecol. 1984 Jul;64(1):101-7.
Serial ultrasound scanning was used routinely in 1687 private patients to detect small-for-gestational-age infants, twins, congenital anomalies, placenta previa, and errors in gestational age estimates. A control population of 8350 private patients was scanned only when indicated. Twenty-three percent of the small-for-gestational-age infants were detected in the control subjects, while routine scanning increased the detection rate to 57% (P = .0007). A high rate of false positive results were found. Seventeen percent of the routinely scanned population were found to be at risk for small-for-gestational age, but only 6% of those actually were small. Despite the increased detection of small-for-gestational-age infants in the routinely scanned population, no significant difference between the routinely scanned and the selectively scanned small-for-gestational-age patients could be shown in the areas of stillborns (6%), neonatal deaths (4%), perinatal mortality (10%), low one-minute (27%) or five-minute (7%) Apgar scores, cesarean section rate (22%), mean gestational age at birth (38.8 weeks), or weight (257 g below the tenth percentile). This occurred despite the aggressive use of maternal bedrest, correction of risk factors, serial scans, nonstress testing, and early delivery when indicated.
对1687名自费患者常规进行系列超声扫描,以检测小于胎龄儿、双胞胎、先天性异常、前置胎盘以及孕周估计错误。8350名自费患者组成的对照组仅在有指征时才进行扫描。对照组中检测出23%的小于胎龄儿,而常规扫描将检出率提高到了57%(P = 0.0007)。发现假阳性结果的发生率很高。常规扫描人群中有17%被发现有小于胎龄风险,但实际上只有6%的人确实是小于胎龄儿。尽管常规扫描人群中小于胎龄儿的检出率有所提高,但在死产率(6%)、新生儿死亡率(4%)、围产期死亡率(10%)、1分钟(27%)或5分钟(7%)阿氏评分低、剖宫产率(22%)、出生时平均孕周(38.8周)或体重(低于第十百分位数257克)等方面,常规扫描的小于胎龄患者与选择性扫描的小于胎龄患者之间没有显著差异。尽管积极采用了孕妇卧床休息、纠正危险因素、系列扫描、无应激试验以及在有指征时提前分娩等措施,但仍出现了上述情况。