Hughey M J, Olive D L
J Reprod Med. 1985 May;30(5):427-30.
One thousand five hundred fifty-one private patients underwent routine ultrasound scanning in part to detect twins. Five thousand nine hundred fifty private patients acted as controls and underwent ultrasound scanning only when indicated by conventional obstetric standards. When diagnosed, twin pregnancy was treated with increased bed rest, nutritional counseling and careful monitoring, with delivery in a tertiary-level center. No significant differences between the two groups could be demonstrated in maternal age, parity or incidence of twin pregnancy. A significant difference could be shown, however, in the early detection of twin pregnancy. By the end of the 24th week, 94% of the twins in the routinely scanned group had been diagnosed as compared to only 68% in the controls (p = 0.03). A significant improvement in perinatal outcome was also demonstrated in the routinely scanned patients as compared to the controls. The incidence of any unfavorable outcome in any infant was reduced from 60% in the controls to 25% in the routinely scanned patients (p = 0.0007). This reduction was due to a reduced incidence of low birth weight, smallness for gestational age, prematurity, depressed Apgar scores and stillbirths. When all twins diagnosed prior to the 25th week of pregnancy were compared with those diagnosed after that week, similar findings were demonstrated.
1551名自费患者接受了常规超声扫描,部分目的是检测双胞胎。5950名自费患者作为对照组,仅在符合传统产科标准时才接受超声扫描。确诊为双胎妊娠后,患者需增加卧床休息、接受营养咨询并进行密切监测,并在三级医疗中心分娩。两组在产妇年龄、产次或双胎妊娠发生率方面无显著差异。然而,在双胎妊娠的早期检测方面存在显著差异。到第24周末,常规扫描组中94%的双胞胎已被诊断出来,而对照组中这一比例仅为68%(p = 0.03)。与对照组相比,常规扫描患者的围产期结局也有显著改善。任何婴儿出现不良结局的发生率从对照组的60%降至常规扫描患者的25%(p = 0.0007)。这一降低是由于低出生体重、小于胎龄、早产、阿氏评分低和死产的发生率降低。将所有在妊娠第25周之前诊断出的双胞胎与在该周之后诊断出的双胞胎进行比较时,也得到了类似的结果。