Lambert-Zechovsky N, Bingen E, Proux M C, Aujard Y, Mathieu H
Pathol Biol (Paris). 1984 May;32(5):439-42.
A differential quantitative study was used to evaluate the effects of parenteral cefoperazone upon children's fecal flora. Fecal specimens were obtained from 16 patients, before, during and after therapy. Cefoperazone therapy was associated with major changes in fecal flora. There was marked reduction or suppression to undetectable levels of Enterobacteria, Staphylococci and Streptococci in 13 patients. During therapy, yeasts were selected or acquired in 7 cases. 5 to 10 days after cefoperazone was discontinued, the fecal flora was virtually the same as before treatment. Thus, cefoperazone should prove very useful in the treatment of septicemia due to intestinal overgrowth.
采用差异定量研究方法评估胃肠外使用头孢哌酮对儿童粪便菌群的影响。在治疗前、治疗期间和治疗后，从16名患者身上采集粪便标本。头孢哌酮治疗与粪便菌群的重大变化有关。13名患者的肠杆菌、葡萄球菌和链球菌显著减少或抑制至检测不到的水平。治疗期间，7例患者出现酵母菌的选择或获得。停用头孢哌酮5至10天后，粪便菌群与治疗前基本相同。因此，头孢哌酮在治疗因肠道菌过度生长引起的败血症方面应非常有用。
