Pasqui L, Bartolomei L, Chemello R, Pellegrini A, Testa G
Riv Neurol. 1984 Mar-Apr;54(2):128-38.
The possible antiepileptic activity of PS has been tested in a model of generalized epilepsy induced by penicillin in the cat. In acute experiments, topical application to the cortex of PS (from 20 mg/ml to 50 mg/ml) produced a reverse in the polarity of the spike and wave complex and, sometimes, a decrease in the voltage as well as a morphological deformation of s-w bursts. Chronic intraperitoneal administration of PS induced a decrease of the epileptic burst frequency. The effect was already apparent after 14 days and of greater extent after 21 days. Finally the antiepileptic effect of 0,2-0,5 mg/Kg diazepam, given in a single dose during the maximal epileptic activity resulted markedly reinforced in animals chronically treated with PS.
PS的抗癫痫活性已在猫青霉素诱发的全身性癫痫模型中进行了测试。在急性实验中，将PS（浓度从20mg/ml至50mg/ml）局部应用于皮质，可使棘波和慢波复合波的极性反转，有时还会使电压降低以及s-w爆发的形态变形。慢性腹膜内给予PS可使癫痫爆发频率降低。该作用在14天后已很明显，在21天后更为显著。最后，在癫痫活动高峰期单次给予0.2-0.5mg/kg地西泮，其抗癫痫作用在长期接受PS治疗的动物中得到显著增强。
