Meyer O, Haïm T, Lansaman J, Dryll A, Ryckewaert A
Rev Rhum Mal Osteoartic. 1984 May;51(5):255-61.
The growth inhibition of in vitro vascular endothelial cell cultures by sera from patients with connective tissue disease was studied. Seven out of 30 sera from patients with progressive systemic sclerosis (PSS) exhibited a cytotoxic effect. The cytotoxic serum factor(s) was not specific to patients with symptoms (11 out of 27 sera from patients with a mixed connective tissue disease, MCTD; 5 out of 34 sera from patients with a systemic lupus erythematosus, SLE). The cytotoxic effect was not specific for vascular endothelial cells, it was also found on fibroblast cells cultures. Inhibitor(s) of cell growth in vitro was independent of antinuclear and anticytoplasmic antibodies and appeared as a common feature of all connective tissue disease with vascular symptoms.
研究了结缔组织病患者血清对体外血管内皮细胞培养物的生长抑制作用。30例进行性系统性硬化症（PSS）患者的血清中有7例表现出细胞毒性作用。细胞毒性血清因子并非有症状患者所特有（27例混合性结缔组织病（MCTD）患者的血清中有11例；34例系统性红斑狼疮（SLE）患者的血清中有5例）。细胞毒性作用并非血管内皮细胞所特有，在成纤维细胞培养物中也有发现。体外细胞生长抑制剂与抗核抗体和抗细胞质抗体无关，似乎是所有有血管症状的结缔组织病的共同特征。
