McHugh N, James I, Maddison P
Royal National Hospital for Rheumatic Diseases, Bath, England.
J Rheumatol. 1990 Oct;17(10):1320-8.
In a series of 163 patients with systemic lupus erythematosus (SLE) and/or systemic sclerosis and/or mixed connective tissue disease (MCTD), the presence of antibodies to a 68 kDa U1RNP associated polypeptide was more predictive for SLE (88%) than for MCTD (38-68%) using 3 different sets of proposed criteria for the latter condition. In all but one case studied serially the immunoblotting profile remained constant. In SLE recognition of the 68 kDa polypeptide identified a subset with increased vasoreactivity with Raynaud's phenomenon (96%, p less than 0.001) and swollen fingers (68%, p less than 0.001) whereas recognition of a 47 kDa La (SSB) polypeptide was associated with photosensitivity (72%, p less than 0.02), less renal involvement (p less than 0.05) and an older age of disease onset (46.6 years +/- 18.3 SD, p less than 0.002).
在一组163例系统性红斑狼疮（SLE）和/或系统性硬化症和/或混合性结缔组织病（MCTD）患者中，使用针对后一种疾病的3套不同的推荐标准，与MCTD（38%-68%）相比，68 kDa U1RNP相关多肽抗体的存在对SLE的预测性更高（88%）。在除1例之外的所有连续研究病例中，免疫印迹图谱保持不变。在SLE中，对68 kDa多肽的识别确定了一个亚组，该亚组雷诺现象（96%，p<0.001）和手指肿胀（68%，p<0.001）的血管反应性增加，而对47 kDa La（SSB）多肽的识别与光敏性（72%，p<0.02）、较少的肾脏受累（p<0.05）以及疾病发病年龄较大（46.6岁±18.3标准差，p<0.002）相关。
