Gollapudi B B, McClintock M L, Linscombe V A, Sinha A K
Toxicol Lett. 1984 Jun;21(3):353-6. doi: 10.1016/0378-4274(84)90096-1.
High doses of a test chemical sometimes affect the food consumption of the treated animals even to the point of starvation. The effect of such a non-specific toxicological stress on the bone marrow micronucleus test was investigated in male and female Sprague-Dawley rats. A 42-h starvation had a noticeable effect on the ratio of polychromatic to normochromatic erythrocytes (PCE and NCE); the values in the starved animals were approx. 77% of the negative controls. An effect of starvation on the frequency of micronucleated erythrocytes (MN-E) was not discernable from the results of the present experiment.
高剂量的受试化学品有时会影响经处理动物的食物摄入量，甚至达到饥饿的程度。在雄性和雌性斯普拉格-道利大鼠中研究了这种非特异性毒理学应激对骨髓微核试验的影响。42小时的饥饿对多染性红细胞与正染性红细胞（PCE和NCE）的比例有显著影响；饥饿动物中的该值约为阴性对照的77%。从本实验结果中无法看出饥饿对微核红细胞（MN-E）频率的影响。
