Aleĭnik S I, Stan E Ia, Chernikov M P
Vopr Pitan. 1984 Mar-Apr(2):47-50.
The products of restricted proteolysis of kappa-casein were separated by gel filtration. Intravenous injection of high- and low-molecular fractions substantially reduced the pentagastrin-stimulated acid secretion in the anesthetized rat stomach. Intermediate fractions had lesser physiological activity. One of the active fractions administered intraintestinally inhibited acid secretion and reduced the pentagastrin-stimulated secretion in rat weanling isolated stomach. All the active fractions inhibited the stimulated secretion in rats with a ligated vagus. It is concluded that the nervous system does not play a crucial role in the mechanism by which gastric acid secretion is inhibited by the products of restricted proteolysis of kappa-casein. Decreasing acid secretion in the stomach, glycopeptide provides for the conditions favouring the efficacy of protein utilization at an early age. It is suggested that the effect of glycopeptide obtained from kappa-casein on the process of assimilation is mediated via peptide hormones.
通过凝胶过滤分离了κ-酪蛋白限制性蛋白水解的产物。向麻醉大鼠的胃中静脉注射高分子和低分子级分可显著降低五肽胃泌素刺激的胃酸分泌。中间级分的生理活性较低。肠内给药的一种活性级分可抑制胃酸分泌，并减少幼龄大鼠离体胃中五肽胃泌素刺激的分泌。所有活性级分均抑制迷走神经结扎大鼠的刺激分泌。得出的结论是，在κ-酪蛋白限制性蛋白水解产物抑制胃酸分泌的机制中，神经系统不起关键作用。糖肽减少胃中的胃酸分泌，为幼年时蛋白质利用效率提供了有利条件。有人提出，从κ-酪蛋白获得的糖肽对同化过程的影响是通过肽激素介导的。
