Tartakovskiĭ I S, Barkhatova O I, Prozorovskiĭ E V
Zh Mikrobiol Epidemiol Immunobiol. 1984 May(5):52-5.
L. pneumophila virulent culture and the filtrate of this culture disintegrated with ultrasound were shown to be toxic for guinea-pig peritoneal macrophages in vitro and for AKR mice. The virulent culture of this infective agent and the filtrate of the supernatant fluid obtained from the washings of its virulent culture had no toxic effect on a macrophage monolayer culture and on mice. The use of these models for characterizing Legionella intracellular toxic activity, as well as for characterizing Legionella strains isolated from patients and the environment, is proposed.
嗜肺军团菌强毒株培养物以及经超声破碎该培养物的滤液在体外对豚鼠腹腔巨噬细胞和AKR小鼠具有毒性。该感染因子的强毒株培养物及其强毒株培养物洗涤液上清液的滤液对巨噬细胞单层培养物和小鼠没有毒性作用。建议使用这些模型来表征军团菌的细胞内毒性活性，以及表征从患者和环境中分离出的军团菌菌株。
