Jansson L, Lindroth M, Työppönen J
Acta Paediatr Scand. 1984 May;73(3):329-32. doi: 10.1111/j.1651-2227.1994.tb17743.x.
Intestinal absorption of dl-alpha-tocopheryl acetate was studied in low birth weight infants. Vitamin E was given from the first day of life, either as a water-soluble (Ephynal) or as a lipid-soluble preparation (E-vitamin). Serum-alpha-tocopherol concentrations were determined before treatment and on days three and seven. Treatment with both vitamin E preparations increased serum-alpha-tocopherol on day three and seven. The mean serum-alpha-tocopherol +/- SD on day seven were 41.4 +/- 10.7 mumol/l for the Ephynal group and 26.7 +/- 12.5 mumol/l for the E-vitamin group, this difference being statistically significant (p less than 0.025). Oral feeding seems to influence the absorption of tocopherol from E-vitamin, as the infants with the highest serum-alpha-tocopherol concentrations were those with the highest oral/total feeding ratios. In infants with birth weight less than 1 000 g treatment with 25 mg Ephynal/day was found to increase serum-alpha-tocopherol on day seven to 46.9 +/- 12.3 mumol/l (mean +/- SD). This concentration is comparable to those reported by others using higher doses of oral vitamin E.
对低出生体重儿的dl-α-生育酚醋酸酯肠道吸收情况进行了研究。从出生第一天起就给予维生素E，剂型为水溶性制剂（埃菲纳尔）或脂溶性制剂（维生素E）。在治疗前以及治疗第3天和第7天测定血清α-生育酚浓度。两种维生素E制剂治疗均使第3天和第7天的血清α-生育酚升高。埃菲纳尔组第7天的平均血清α-生育酚±标准差为41.4±10.7μmol/L，维生素E组为26.7±12.5μmol/L，这一差异具有统计学意义（p＜0.025）。口服喂养似乎会影响维生素E中生育酚的吸收，因为血清α-生育酚浓度最高的婴儿是口服/总喂养比例最高的婴儿。在出生体重低于1000g的婴儿中，发现每天给予25mg埃菲纳尔治疗可使第7天的血清α-生育酚升高至46.9±12.3μmol/L（平均±标准差）。该浓度与其他使用更高剂量口服维生素E的报告结果相当。
