Aihara K, Nishi Y, Hatano S, Kihara M, Yoshimitsu K, Takeichi N, Ito T, Ezaki H, Usui T
Am J Clin Nutr. 1984 Jul;40(1):26-35. doi: 10.1093/ajcn/40.1.26.
This study was designed to evaluate trace metal metabolism in adults with thyroid diseases. Erythrocyte zinc values were significantly lower than normal in hyperthyroidism and higher in hypothyroidism. A significantly higher than normal urinary excretion of zinc was observed in hyperthyroidism. The mean concentrations of plasma and erythrocyte copper were significantly above normal in hyperthyroidism. Plasma selenium levels were significantly lower than normal in hyperthyroidism. No statistically significant difference was found in plasma zinc, erythrocyte manganese, or urine copper values between patients with thyroid diseases and healthy controls. The erythrocyte manganese content correlated well with thyroxine and triiodothyronine levels. Plasma prealbumin and retinol-binding protein correlated well with the erythrocyte zinc content but not with plasma zinc levels. There was no correlation between erythrocyte superoxide dismutase activity and erythrocyte copper or zinc concentrations. The results of this study suggest that the metabolism of zinc, copper, manganese, and selenium is abnormal in thyroid diseases.
本研究旨在评估甲状腺疾病成人患者的微量金属代谢情况。甲状腺功能亢进患者的红细胞锌值显著低于正常水平，而甲状腺功能减退患者的则高于正常水平。甲状腺功能亢进患者的尿锌排泄量显著高于正常水平。甲状腺功能亢进患者血浆和红细胞铜的平均浓度显著高于正常水平。甲状腺功能亢进患者的血浆硒水平显著低于正常水平。甲状腺疾病患者与健康对照者在血浆锌、红细胞锰或尿铜值方面未发现统计学上的显著差异。红细胞锰含量与甲状腺素和三碘甲状腺原氨酸水平密切相关。血浆前白蛋白和视黄醇结合蛋白与红细胞锌含量密切相关，但与血浆锌水平无关。红细胞超氧化物歧化酶活性与红细胞铜或锌浓度之间无相关性。本研究结果表明，甲状腺疾病患者锌、铜、锰和硒的代谢异常。
